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Ketorolac: Increased risk of gastrointestinal bleeding, peptic ulcer disease, and acute kidney injury in older adults Opioid analgesic that causes CNS adverse effects, including confusion and hallucinations, more commonly than other opioid analgesic drugs; is also a mixed agonist and antagonist; safer alternatives available Most muscle relaxants poorly tolerated by older adults because some have anticholinergic adverse effects, sedation, increased risk of fractures; effectiveness at dosages tolerated by older adults questionable The primary target audience is practicing clinicians.