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This sedating activity is sometimes used in managing conditions such as eczema where sleep maybe disturbed due to pruritus.Sedating antihistamines also have significant antimuscarinic activity and should be used with caution in patients with prostatic hypertrophy, urinary retention and angle-closure glaucoma.Examples of sedating antihistamines: Sedation is rare with non-sedating antihistamines, however patients should be made aware that a sedative effect may occur and performance of skilled tasks such as operating machinery or driving maybe affected.We are a privately owned Biotechnology company in the Republic of South Africa located in the City of Johannesburg, the technological hub and business innovation centre of South Africa.Medications used in the treatment of insomnia include nonbenzodiazepine receptor agonists, benzodiazepine receptor agonists, the selective melatonin receptor agonist ramelteon, and sedating antidepressants.All can be considered first-line agents for insomnia; agent choice is largely dictated by past trials, cost, side-effect profile, drug interactions, and patient preference.Sedative-hypnotics include nonbenzodiazepine receptor agonists (zaleplon, zolpidem, eszopiclone); short-acting benzodiazepine receptor agonists (triazolam); intermediate-acting benzodiazepine receptor agonists (estazolam, temazepam); and selective melatonin agonists (ramelteon).

Sedating antihistamines cause sedation as they are highly lipid soluble and readily cross the blood brain barrier.

* Oncology * Dermatology * Infectious Diseases ( Including HIV & TB) * Immunology * Opthalmology * Over The Counter (OTC Medication) Our portfolio of products and healthcare technologies are carefully selected to meet the health-related needs of Healthcare Practitioners and Patients on the continent of Africa.

BGM and its technology partners are also developing a significant portfolio of Theranostics based on novel Radiopharmaceuticals aimed at the Global Cancer and Immunology market.

By binding to specific subunits of GABA Benzodiazepines are on the Beer’s List of potentially inappropriate medications for older patients.

They are not recommended in the elderly because of the risk of falls; if used, they should be given at the lowest effective dose for the shortest amount of time.